Yes. While it's not required per the spec, the following is mentioned in RFC6265 (emphasis is in the original document, not added)
To maximize compatibility with user agents, servers that wish to
store arbitrary data in a cookie-value SHOULD encode that data, for
example, using Base64 [RFC4648].
In my experience, most web frameworks and libraries for cookies have methods for encoding/decoding cookie values. In many cases, esp. in frameworks and high-level languages, this is abstracted away and done automatically.
This answer provides a fairly detailed of the history behind the values allowed in cookies. Might be of interest to you.
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