This is quite possible and easy to do.
Simply use dbms_lob.instr in conjunction with utl_raw.cast_to_raw
So in your case, if t1 is a BLOB the select would look like:
select *
from table1
where dbms_lob.instr (t1, -- the blob
utl_raw.cast_to_raw ('foo'), -- the search string cast to raw
1, -- where to start. i.e. offset
1 -- Which occurrance i.e. 1=first
) > 0 -- location of occurrence. Here I don't care. Just find any
;
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