Yes, you can use target="_parent" to achieve this.
"target="_parent" opens the linked document in the parent frame."
Example:
<a target="_parent" href="http://example.org">Click me!</a>
Edit:
If that's not working, you can try _top
:
<a target="_top" href="http://example.org">Click me!</a>
Or base target
:
<base target="_parent" />
Or window.top.location
in JavaScript:
window.top.location = "http://example.com";
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