I wouldn't recommend using STRAIGHT_JOIN without a good reason. My own experience is that the MySQL query optimizer chooses a poor query plan more often than I'd like, but not often enough that you should just bypass it in general, which is what you would be doing if you always used STRAIGHT_JOIN.
My recommendation is to leave all queries as regular JOINs. If you discover that one query is using a sub-optimal query plan, I would suggest first trying to rewrite or re-structure the query a bit to see if the optimizer will then pick a better query plan. Also, for innodb at least, make sure it's not just that your index statistics are out-of-date (ANALYZE TABLE). That can cause the optimizer to choose a poor query plan. Optimizer hints should generally be your last resort.
Another reason not to use query hints is that your data distribution may change over time, or your index selectivity may change, etc. as your table grows. Your query hints that are optimal now, may become sub-optimal over time. But the optimizer will be unable to adapt the query plan because of your now outdated hints. You stay more flexible if you allow the optimizer to make the decisions.
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