If it's iframe :
the I would suggest you to switch to frame like this (with explicit waits):
wait = WebDriverWait(driver, 10)
wait.until(EC.frame_to_be_available_and_switch_to_it((By.ID, "iframe ID")))
Imports :
from selenium.webdriver.support.ui import WebDriverWait
from selenium.webdriver.common.by import By
from selenium.webdriver.support import expected_conditions as EC
once you have switched you can click like this :
wait.until(EC.element_to_be_clickable((By.CSS_SELECTOR, "#downloadButton"))).click()
and click on close :
wait.until(EC.element_to_be_clickable((By.ID, "btnZorgAnnuleren"))).click()
and once you are done, you should switch to default content like this :
driver.switch_to.default_content()
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