The purpose of My, as I understand it, is to be an easy shortcut to certain API tasks that are common but hard-to-find or hard-to-use. You probably shouldn't completely subsume your framework under My. (For one thing, C# people using your framework may get grouchy.)
Instead, you should design it as a normal framework. When you're finished, make a list of some common tasks that people might want to use your framework for. See whether any of those could be useful to have under My, especially where there are classes or methods that can be used in a number of ways, but they have one or two really common usages that can be abbreviated with My.
This article shows how to extend My, and it has a section at the end that describes a few design guidelines to follow: Simplify Common Tasks by Customizing the My Namespace
As to your main question, when coding in VB .NET, I use My as often as I can. It reduces a number of operations to one line of code.
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